e.,
their delayed-release properties, were not affected by the agglomeration process. The gastro-resistance of the agglomerates was affected by the amount of spray-dried mannitol/lecithin powders. The ratio of lecithin in the spray-dried mannitol/lecithin powders was the key factor in the agglomerate formation and in the drug release profiles. The agglomerates presenting better mechanical and biopharmaceutical characteristics were prepared with 1:2 (w/w) ratio of pantoprazole-loaded microparticles and mannitol/lecithin (80:20) powder.”
“Five novel phenolic glycosides, adenophorasides A (1), B (2), C (3), D (4), and E (5), were isolated from commercial Adenophora roots, together with vanilloloside (6), 3,4-dimethoxybenzyl alcohol 7-O-beta-d-glucopyranoside (7), and lobetyolin selleck kinase inhibitor Danusertib (8). The structures of the new compounds (1-5) were characterized as 4-hydroxy-3-methoxyphenylacetonitrile 4-O-beta-d-glucopyranoside (1), 4-hydroxy-3-methoxyphenylacetonitrile
4-O-beta-d-glucopyranosyl-(1 -> 6)-beta-d-glucopyranoside (2), 4-hydroxy-3-methoxyphenylacetonitrile 4-O-alpha-l-rhamnopyranosyl-(1 -> 6)-beta-d-glucopyranoside (3), 4-hydroxyphenylacetonitrile 4-O-beta-d-glucopyranosyl-(1 -> 6)-beta-d-glucopyranoside (4), and 4-hydroxy-3-methoxybenzyl alcohol 4-O-beta-d-glucopyranosyl-(1 -> 6)-beta-d-glucopyranoside (5), respectively, by means of spectroscopic and chemical analyses.”
“Study Design. Cross-sectional mail questionnaire.
Objective. Examination of the underlying construct validity of the Scoliosis Research Society-22r (SRS-22r) Health-Related Quality of Life (HRQoL) Questionnaire using factor analysis.
Summary of Background Data. The original SRS-24 HRQoL questionnaire has undergone a series of modifications in an effort to further improve its psychometric properties and validate its use in patients from 10 years of age until well into adulthood. The SRS-22r questionnaire is the result of this effort. To date, the underlying construct validity of the original English version has not been analyzed by factor analysis.
Methods. A
questionnaire selleck products including all questions on the SRS-24, -23, -22, and -22r questionnaires (49 total questions) was mailed to a consecutive series of 235 patients who had received primary posterior or anterior instrumentation and arthrodesis. Domain structure of the SRS-22r questions was analyzed using iterated principal factor analysis with orthogonal rotation.
Results. One hundred twenty-one (51%) of the patients, age 23.34 +/- 4.52 years (range, 14.16-34.57 years), returned the questionnaire at 8.63 +/- 4.00 years (range, 2.32-15.94 years) following surgery. Factor analysis using all 22 questions resulted in 3 factors with many shared items because of significant collinearity of the satisfaction/dissatisfaction with management questions with the others. After 18 iterations, factor analysis using the 20 nonmanagement questions revealed 4 factors that explained 98% of the variance.