3. Discussion Laparoscopic liver resection has proven safe and feasible and can be performed according to established oncological principles in institutions with experience in both hepatobiliary and advanced laparoscopic surgery [1]. The minimally invasive kinase inhibitor Dasatinib approach has several documented advantages such as fast recovery and cosmetic superiority and may even have some immunological benefits in malignant disease. The development of modern surgical tools has enabled us to perform these resections with minimal bleeding and excellent visual control. Our recently published series of laparoscopic liver resection has shown that such resections can be performed with excellent perioperative results and oncological outcome compared to traditional, open surgery.

The search for even less invasive methods the last few years has led to the development of Natural Orifice Transluminal Endoscopic Surgery (NOTES) techniques as well as the development of equipment enabling surgery through single incisions. Several companies now deliver specially designed products for such procedures. To date, a wide variety of single incision surgical procedures have been reported, including cholecystectomy, appendectomy, adrenalectomy, splenectomy, and colectomy. Liver resections by the single incision have been scarely reported and certainly not as a simultaneous procedure through a bowel stoma site following reversal of a loop enterostomy. It is obvious that not all metastatic lesions of the liver are suitable for this technique. In our experience, the preferred lesions would be superficially located on the anterior aspect of the liver.

Such lesions will not demand extensive triangulation, major mobilization, or retraction of the remnant liver. The technique is also suitable for smaller anatomical resections such as resection of segment 2/3 as suggested in a recent publication [4]. The ideal timing from resection of a synchronous liver metastasis from a colorectal carcinoma is not known. Neo-adjuvant or adjuvant chemotherapy is gaining acceptance as standard of care in many institutions, and recently published data indicates increased long-term survival and longer disease-free survival following this approach [5, 6]. In the present case report, a neoadjuvant chemotherapy algorithm had not been implemented in our institution, but the patient’s age and pre-existing renal failure would in any case have contraindicated chemotherapy.

Although simultaneous surgery for a primary colorectal adenocarcinoma Anacetrapib and combined liver surgery may be considered safe in selected cases, many centers still choose a two-stage procedure [7]. In patients with high risk of anastomosis complications, which may be the case in some low anterior resections for rectal cancer, one may consider performing a laparoscopic liver resection prior to resection of the primary tumor in order to prevent delay in the treatment of liver metastases.