This can be explained by the differences in generation time and winter survival between the flies and wing-mites. Our study thus exemplifies that the population genetic structure of parasites on a single host can vary strongly as a result of how their individual life history characteristics interact with host behaviour and life history traits.”
“A major paradigm shift in cancer research is the emergence
of multidisciplinary approaches to investigate complex cell behaviors, to elucidate regulatory mechanisms and to identify therapeutic targets. Recently, efforts are focused on the engineering of complex in vitro models, which more accurately recapitulate the growth and progression of cancer. These strategies have proven vital for investigating and targeting the events that control tumor angiogenesis. In this review, we explore how the emerging SCH 900776 in vivo engineering approaches are being used to unlock the complex mechanisms regulating tumor angiogenesis. Emphasis is placed on models using natural and synthetic biomaterials to generate scaffolds mimicking the extracellular matrix, which is known to play a critical role in angiogenesis. While the models presented in this review are revolutionary, improvements are still necessary and concepts for advancing and perfecting engineering approaches for modeling tumor angiogenesis
STI571 cell line are proposed. Overall, the marriage between disparate scientific fields is expected to yield significant improvements in our understanding and treatment of cancer. Cancer Res; 72(23); 6089-96. (C) 2012 AACR.”
“Alzheimer’s Disease (AD) is a neurodegenerative disorder that affects millions of individuals worldwide. Accumulation of amyloid-peptide
(A beta) in the brain, and its aggregation into oligomers, fibrils and plaques, plays a central role in the onset and development of AD. Starting from this observation, the E.C. FP7 project “NAD” (Nanoparticles for therapy and diagnosis of Alzheimer’s disease) is involved in the design of nanoparticles that recognize Bucladesine and remove brain All Previous investigations by NAD Consortium have already produced nanoparticles containing anionic phospholipids or curcumin-analogues able to bind A beta with very high affinity, to inhibit fibril formation and to reduce A beta toxicity in-vitro. Starting from the observation that ganglioside GT1b binds A beta in vitro, we have synthesized liposomes, composed of sphingomyelin and cholesterol and containing GT1b ganglioside, and investigated their affinity towards A beta peptide. Surface Plasmon Resonance experiments showed a good interaction of liposomes with A beta fibrils, displaying Kd values between 125 and 150 nM. Moreover, A beta aggregation into fibrils, measured by Thioflavin T and Congo Red binding assays, was reduced of about 50%, after two weeks of monomeric peptide incubation in the presence of GT1b-containing liposomes.