“As increasing numbers of elderly patients require solid organ transplantation, the need to better understand how aging modifies alloimmune responses increases. Here, we examined whether aged mice exhibit augmented, donor-specific memory responses prior to transplantation.
We found that elevated donor-specific IL-17, but not IFN-gamma, responses were observed in aged selleck screening library mice compared to young mice prior to transplantation. Further characterization of the heightened IL-17 alloimmune response with aging demonstrated that memory CD4(+) T cells were required. Reduced IL-2 alloimmune responses with age contributed to the elevated IL-17 phenotype in vitro, and treatment with an anti-IL-17 antibody delayed the onset of acute allograft rejection. In conclusion, aging leads to augmented, donor-specific IL-17 immune responses that are important for the timing of acute allograft rejection in aged recipients. Selleckchem JQEZ5 IL-17 targeting therapies may be useful for averting transplant rejection responses in older transplant recipients.”
“Metachromatic leukodystrophy is an autosomal recessive neurodegenerative lysosomal disease characterized by a deficiency of the lysosomal enzyme arylsulfatase A and the subsequent accumulation of sulfatide in neuronal and visceral tissues. Clinical diagnosis is usually confirmed by in vitro analysis of arylsulfatase
A activity but may be complicated in cases of arylsulfatase A pseudodeficiency and sphingolipid activators protein deficiency. We report the case of a 3-year-old boy who presented a severe form of late infantile metachromatic leukodystrophy. This patient was found to be homozygous for the arylsulfatase A pseudodeficiency. This condition is rare and can lead to a severe disease.
Prenatal diagnosis was performed in this family, and the fetus was health.”
“Purpose: The purpose of this study was to examine the relationships among internal health locus of control, depression, social support, and health-promoting behaviors in Korean breast cancer survivors and to identify factors influencing health-promoting behaviors.
Method: A predictive design was used. The data were collected by questionnaires from a convenience sample of 258 breast cancer survivors in Korea during 2007. The data were analyzed using S3I-201 mw descriptive statistics, t-tests, one-way ANOVA, Pearson’s correlation coefficients, and stepwise multiple regression.
Results: When differences of health-promoting lifestyle based on demographic and illness-related characteristics were examined, no significant differences were found except for undergoing chemotherapy. Internal health locus of control, depression, and social support were correlated significantly with the health-promoting lifestyle. As a result of stepwise multiple regression analysis, social support, depression, and chemotherapy were discovered to account for 34.