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H, Tempst P, Tarakhovsky A: BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism. J Exp Med 2006, 203:2551–2562.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions JZ proposed the study and wrote the first draft. LS and SSL modified

the draft. RPZ contributed to the design of the study. LQZ and DDF helped analyzed the data. LC, JL and WTS aided with manuscript preparation. Carnitine palmitoyltransferase II LYZ and STY provided the necessary funding. All authors read and approved the final manuscript.”
“Background Gastric cancer remains the second most common cause of cancer-related death worldwide [1, 2]. Many Asian countries, including China, Japan, and Korea, still have very high incidences of and mortality from gastric cancer. Despite progress in early diagnosis of gastric cancer, many patients present with unresectable, locally advanced, or metastatic disease associated with an extremely poor prognosis. Most cases of advanced gastric cancer remain incurable, with a median survival of only 6-12 months even in patients who receive intensive chemotherapy [3–7]. Trastuzumab, a monoclonal antibody against human epidermal growth factor receptor 2 (HER2), is therapeutically effective in gastric cancer. However, 22% of all advanced or metastatic gastric cancers showed HER2 overexpression in one clinical trial [8].