For the oil spill predictions in the sea area around Crete, sea currents and sea surface temperatures have been acquired from the ALERMO (Aegean Levantine Regional Model) (Korres and Lascaratos, 2003 and Sofianos

et al., 2006). The ALERMO is downscaling from MyOcean (www.myocean.eu) regional MFS (Mediterranean Forecasting System) (Pinardi et al., 2007, Tonani et al., 2008 and Oddo et al., 2010) and covers the Eastern Mediterranean Ipatasertib price with forecast data every 6 h, with a horizontal resolution of 3 km. Both the MyOcean regional MFS and the downscaled ALERMO model use satellite-derived sea surface altimetry and available in-situ data. Wind data were obtained from SKIRON (Kallos and SKIRON group, 1998a, Kallos and SKIRON group, 1998b, Kallos and SKIRON group, 1998c, Kallos and SKIRON group, 1998d, Kallos and SKIRON group, 1998e and Kallos and SKIRON group, 1998f) as high frequency weather forecasts (every hour with a 5-km horizontal resolution), while wave data were obtained from CYCOFOS every 3 h, with a 10-km horizontal resolution (Galanis et al., 2012,

Zodiatis et al., 2014a and Zodiatis et al., 2014b). The three-step method proposed in this paper can be summarised as follows: (1) Bathymetric, geomorphological, geological and oceanographic data for the area of interest are initially acquired and analysed, considering these parameters buy INCB024360 as key to the dispersion of oil slicks in offshore areas. In this initial step, the morphological structure of onshore and offshore areas in Crete (Panagiotakis and Kokinou, in press) was analysed using bathymetric, elevation data, and their derivatives

(slope and aspect). Our aim was to select the areas of the possible oil spill accidents near to: (a) major sea-bottom features, (b) urban areas with important infrastructures and tourism sites, and (c) coastal regions showing high sensitivity to oil pollution due to their morphology and structure. Slope and aspect features are calculated for each point p of a bathymetric/topographic surface Z using the plane tangent vector u(p): equation(1) u(p)=∂Z(p)∂x,∂Z(p)∂yT Slope S  (p  ) is defined as the maximum rate of change in bathymetry or altitude. Thus, the (-)-p-Bromotetramisole Oxalate rates of surface change in the horizontal ∂Z(p)∂x and vertical ∂Z(p)∂y directions from the point p   can be used to determine the slope angle S  (p  ): equation(2) S(p)=tan-1(|u(p)|2)S(p)=tan-1u(p)2where tan−1 is the arctangent function and |u(p)|2u(p)2is the Euclidean norm of the vector u(p). Aspect identifies the downslope direction of the maximum rate of change in the value from each point to its neighbours. Therefore, it holds that Aspect can be defined as the slope direction on horizontal plane: equation(3) A(p)=atan2∂Z(p)∂y,-∂Z(p)∂xwhere a   tan 2 is the arctangent function with two arguments. The parameter a   tan 2(y  , x  ) is the angle between the positive x  -axis of a plane and the point given by the coordinates (x  , y  ) on this same plane.