In a multiple regression analysis, smoking was independently associated with intact PTH (beta=0.29, p=0.002) Selleckchem ARN-509 and PTH1-84 (beta=0.29, p=0.002). Fifty-six of 161 patients (35%) were classified as having hyperparathyroidism. In a multiple logistic regression model the odds of hyperparathyroidism were about 4 times higher in heavy smokers (odds ratio 3.88, 95% CI 1.16-12.92, p=0.027) than in nonsmokers.

Conclusion: In dialysis patients heavy smoking is independently associated

with high levels of intact PTH and PTH1-84. Further observational, mechanistic and interventional studies are needed to assess the nature (causal or noncausal) of these links in ESRD.”
“Objective: To investigate

the relationship between Metabolic Bone Disease (MBD) and Transient Hypothyroxinemia of Prematurity click here (THOP).

Method: One hundred twenty-four infants, born in Marmara University Hospital with a gestational age <= 34 weeks, were enrolled. Clinical features were recorded. Serum TSH, free T-4, total T-4, calcium, phosphorus and total Alkaline Phosphatase (ALP) levels were determined in the first and third postnatal weeks. MBD was defined as a phosphorus level <4.5 mg/dl and/or ALP >900 IU/l. THOP was defined as a serum free and/or total thyroxine level lower than -1 SD for gestational age at the 7th postnatal day.

Result: THOP was diagnosed in nineteen (15.3%) patients. MBD was diagnosed in 52 (41.9%) at the 3rd month. Low birth weight, low gestational age and prolonged parenteral nutrition were associated with MBD. Multivariate analysis documented a significant relationship solely between MBD and gestational age.

Conclusion: The risk of MBD does not increase significantly in babies with THOP.”
“P>Background:

After surgical repair of congenital heart disease, inotropic support is sometimes necessary to wean from cardiopulmonary bypass. In pediatric cardiac surgery, dobutamine and dopamine are often used as inotropic support. Dopexamine is a synthetic catecholamine, which has positive inotropic and vasodilating

properties. Because the hemodynamic effects of catecholamines are modified after cardiopulmonary bypass, the aim of this study was to investigate the www.selleckchem.com/products/Adriamycin.html effects of dobutamine and dopexamine on cardiac index and systemic vascular resistance index after cardiopulmonary bypass in pediatric cardiac surgery.

Methods:

The study was performed in a prospective, randomized, and double-blinded cross-over design. The investigation included 11 children for elective, noncomplex congenital heart surgery. After weaning from cardiopulmonary bypass and a 20-min period of steady state, children received either 2.5 mu g center dot kg(-1)center dot min(-1) dobutamine or 1 mu g center dot kg(-1)center dot min(-1) dopexamine for 20 min.