Key words: harm avoidance, Alzheimer’s disease, mild cognitive impairment, cognitive decline, longitudinal studies, brain autopsy.”
“Secondary malignancies are well established complication in long-term survivors

after allogeneic stem-cell transplantation (SCT) with myeloablative conditioning (MAC). Fludarabine-based reduced-intensity (RIC) and reduced-toxicity conditioning (RTC) regimens are increasingly used in the last decade; however, due to limited long-term follow-up, there is no data on secondary malignancies in this setting. The records of 931 consecutive patients given allogeneic SCT with MAC (n = 257), RIC (n = 449) or RTC (n = 225), in a single institution over a 13-year period, were reviewed. Twenty-seven Cisplatin datasheet patients had secondary malignancy, diagnosed a median of 43 months (7 months-11.5 years) after SCT. The 10-year cumulative H 89 clinical trial incidence was 5.6% (95% confidence interval (CI), 3.6-8.7), twice the expected rate in matched normal population. The incidence was 1.7, 7.4 and 5.7% after MAC, RIC and RTC, respectively (P = 0.02). Multivariate analysis identified fludarabine-based conditioning (hazard ratio (HR) 3.5, P = 0.05), moderate-severe chronic graft-versus-host disease (HR 2.8, P = 0.01) and diagnosis of chronic myeloproliferative or non-malignant disease (HR 0.2, P = 0.04) as risk-factors for secondary malignancy. The

related 10-year mortality rate was 2.4% (95% CI, 1.0-5.4). In conclusion, the risk of secondary malignancies is not reduced and is even possibly increased in the era of

fludarabine-based RIC/RTC. Patients and physicians should be aware of this association and life-long cancer screening is required for all transplant survivors. Leukemia (2013) 27, 829-835; doi:10.1038/leu.2012.299″
“Objective: This study examined associations between lifetime trauma exposures, PTSD and partial PTSD, and past-year medical conditions BRSK2 in a nationally representative sample of US adults. Methods: Face-to-face interviews were conducted with 34,653 participants in the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. Logistic regression analyses evaluated associations of trauma exposure, PTSD, and partial PTSD with respondent-reported medical diagnoses. Results: After adjustment for sociodemographic characteristics and comorbid Axis I and II disorders, respondents with full PTSD were more likely than traumatized respondents without full or partial PTSD (comparison group) to report diagnoses of diabetes mellitus, noncirrhotic liver disease, angina pectoris, tachycardia, hypercholesterolemia, other heart disease, stomach ulcer, human immunodeficiency virus seropositivity, gastritis, and arthritis (odds ratios [ORs] = 1.2-2.5). Respondents with partial PTSD were more likely than the comparison group to report past-year diagnoses of stomach ulcer, angina pectoris, tachycardia, and arthritis (ORs = 1.3-1.6).