McDonnell Foundation. We thank Priya Velu, Laura Johnson Susan Davis, Brittany Masatsugu, Danielle Dickson, and

Fan Li for their assistance. The rodent-shaping methods and training technology were developed by Philip Meier, E.D.F., and P.R. “
“The primate dorsolateral prefrontal cortex (dlPFC) is thought to play an important role in executive functions such as working memory, response inhibition, preparation for action, goal selection, planning, and decision making (Tanji and Hoshi, 2008). Previous studies in nonhuman primates have reported that dlPFC neurons selectively respond to stimuli that are relevant to a given task, suggesting that these units play a role in attentional filtering of behaviorally relevant signals from irrelevant ones (Boussaoud this website and Wise, 1993, di Pellegrino and Wise, 1993, Everling et al., 2002, Lebedev et al., 2004 and Rainer et al., 1998). However, Doxorubicin a similar response pattern is shown by neurons in other brain areas such as the frontal eye fields (FEFs) (Thompson and Bichot, 2005), area lateral intraparietal

(LIP) (Bisley and Goldberg, 2003 and Goldberg et al., 2006), and the superior colliculus in the brainstem (Fecteau and Munoz, 2006 and Ignashchenkova et al., 2004), raising the question of what are the specific roles of the dlPFC and each one of these areas in attentional filtering. A recent study has shown that during voluntary allocation of attention to a visual target in the presence of distracters, dlPFC and FEF neurons selectively represent the target location through their firing patterns earlier than neurons in area LIP (Buschman and Miller, 2007 and Buschman and Miller, 2009), suggesting that top-down attentional signals may emanate first in the prefrontal cortex and then propagate throughout the

rest of the brain (but see Schall et al., 2007 and Buschman and Miller, 2009). Moreover, it has been suggested that the FEF plays a role in shifting attention toward a target location, regardless of whether the target is present or absent, whereas the dlPFC signals the current target position (Buschman and Miller, 2009). However, because data comparing the specific roles of dlPFC and FEF in generating attentional signals are scarce, this issue remains poorly understood. Over the last decade, studies in monkeys have reported that microstimulation of the FEF causes enhanced detection performance at below selected locations in the visual field (Moore and Fallah, 2001) as well as increases in the firing rate of V4 neurons with receptive fields (RFs) at that location (Moore and Armstrong 2003). Additionally, the strength of FEF activation correlates with changes in the animals’ performance during attentional tasks (Armstrong et al., 2009 and Gregoriou et al., 2009). In the dlPFC, although it has been reported that attentional filtering by single neurons is strong and shows selectivity not only for spatial locations but also for stimulus type (Everling et al.