Often, today, prenatal care allows the diagnosis of fetal problems or of maternal conditions that put the fetus at risk. Such diagnoses may lead to a medically induced preterm birth. When done appropriately, medically induced preterm births can lower the rate of both stillbirth and neonatal morbidity and mortality.12 Thus, better prenatal care might

actually cause more preterm birth, but the increase in preterm birth might lead to decreased rates of both fetal and infant mortality. By this view, prenatal care should be seen less as a preventive treatment and more an intervention designed to identify and respond to problems that threaten Inhibitors,research,lifescience,medical the health of fetuses. We will discuss each of these explanations and show how they might each be a part of the story. Finally, we analyze the implications of these analyses. DOES PRENATAL CARE WORK? In the 1980s, the conventional wisdom was that better access

to prenatal care would lead to lower rates of preterm birth and lower costs. The studies that led to this conventional wisdom generally compared women who received little Inhibitors,research,lifescience,medical or no prenatal care with women who received CPI-613 nmr adequate prenatal care. In those studies, the women who received adequate prenatal Inhibitors,research,lifescience,medical care had dramatically better outcomes. For example, Leveno and colleagues published such an analysis in 1985: “Women seeking prenatal care had a significantly decreased incidence of low birth weight infants compared with those without such care … Prenatal care was associated with a 50% decrease in costs

for each infant.”13 In a 1986 study, Moore and colleagues studied infants who were born at the University of California at San Diego. They compared Inhibitors,research,lifescience,medical infants whose mothers had received fewer than three prenatal visits with those whose mothers had received care in a comprehensive perinatal program. Inhibitors,research,lifescience,medical They showed: When the total inpatient hospital charges were tabulated for each mother-baby pair, the cost of perinatal care for the group receiving no care ($5168 per pair) was significantly higher than the cost for patients in the Comprehensive Perinatal Program ($2974 per pair, P<0.001) including an antenatal charge of $600 in the Comprehensive Perinatal Program. The excess cost for delivery of 400 women receiving no care per year in the study hospital was $877,600.14 Joyce and colleagues, in a study done for the National Bureau of Economic Research, compared prenatal care with other interventions that might also reduce Sodium butyrate infant mortality. They compared teenage family planning, the supplemental food program for women, infants, and children (WIC), the use of community health centers and maternal and infant care projects, abortion, prenatal care, and neonatal intensive care. Their primary outcome measure was dollars (1984 dollars) per life saved. They showed that prenatal care was the most cost-effective of all these interventions, with a cost of about $30,000 per life saved. By contrast, neonatal intensive care, by their estimates, cost over $2 million per life saved.