PubMed 151. Bluth MJ, Zaba LC, Moussai D, Suarez-Farinas M, Kaporis H, Fan L, Pierson KC, White TR, Pitts-Kiefer A, Fuentes-Duculan J, Guttman-Yassky E, Krueger JG, Lowes MA, Carucci JA: Myeloid dendritic cells from human cutaneous squamous cell carcinoma are poor stimulators of T-cell proliferation. J Invest Dermatol 2009, 129:2451–2462.PubMed 152. Pak AS, Wright MA, Matthews JP, Collins SL, Petruzzelli
GJ, Young MR: Mechanisms of immune suppression in patients with head and neck cancer: presence of CD34 + cells which suppress immune functions within cancers that secrete granulocyte-macrophage colony-stimulating factor. Clin Cancer Res 1995, 1:95–103.PubMed 153. Young MR, Wright MA, Lozano Y, Matthews JP, Benefield J, Prechel MM: Mechanisms of immune suppression
in patients with head and neck cancer: influence on the immune infiltrate of the cancer. Int J Cancer 1996, 67:333–338.PubMed 154. Young MR, Wright MA, Lozano Y, Prechel MM, Benefield J, Leonetti Smad cancer JP, Collins SL, Petruzzelli GJ: Increased Captisol mw recurrence and metastasis in patients whose primary head and neck squamous cell carcinomas secreted granulocyte-macrophage colony-stimulating factor and contained CD34 + natural suppressor cells. Int J Cancer 1997, 74:69–74.PubMed 155. RXDX-101 mw Norian LA, Rodriguez PC, O’Mara LA, Zabaleta J, Ochoa AC, Cella M, Allen PM: Tumor-infiltrating regulatory dendritic cells inhibit CD8 + T cell function via L-arginine metabolism. Cancer Res 2009, 69:3086–3094.PubMed 156. Hoechst B, Voigtlaender T, Ormandy L, Gamrekelashvili J, Zhao F, Wedemeyer H, Lehner F, Manns MP, Greten TF, Korangy F: Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor. Hepatology 2009, 50:799–807.PubMed 157. Kusmartsev S, Su Z, Heiser A, Dannull J, Eruslanov E, Kubler H, Yancey D, Dahm P, Vieweg J: Reversal of myeloid cell-mediated immunosuppression in patients with metastatic renal cell carcinoma. Clin Cancer DNA ligase Res 2008, 14:8270–8278.PubMed 158. Zea AH, Rodriguez PC, Atkins MB, Hernandez C, Signoretti S, Zabaleta J, McDermott D, Quiceno D, Youmans
A, O’Neill A, Mier J, Ochoa AC: Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. Cancer Res 2005, 65:3044–3048.PubMed 159. Hoechst B, Ormandy LA, Ballmaier M, Lehner F, Kruger C, Manns MP, Greten TF, Korangy F: A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4 + CD25 + Foxp3 + T cells. Gastroenterology 2008, 135:234–243.PubMed Competing interests The authors declare that they have no competing interests. Authors’ contributions YW initiated the concept. CD drafted the manuscript. Both authors participated in writing, read and approved the final manuscript.”
“Introduction & statement of the problem One of the bacterial agents that has been found to be regularly associated with colorectal cancer is Streptococcus bovis (S. bovis). S.