Results: 1. Among the patients who were enrolled in our study, 36 were
male, 12 were female. The age of patients in this study ranges from 34 to 85, with an average of 59.4 ± 11.2. 24 of the patient age from 34 to 60, the other 24 were above 60 year old. Among these patients, the adenocarcinoma area of 19 cases located at the pyloric antrum, 29 cases at the body of stomach. 31 cases had lymph node metastasis, 17 cases had no lymph node metastasis. 25 cases were highly or moderately differentiated, 23 cases were poorly differentiated. 18 cases were in TNM stage I-II, and 30 cases were in TNM stage III-VI. 2. The positive expression rate of Selleckchem SB203580 VIP in gastric carcinoma tissue (94%) was significantly higher than its normal peripheral tissue (77%)(P < 0.05). The expression intensity of VIP in gastric carcinoma was significantly higher than its normal peripheral tissue (P < 0.01). The VIP expression intensity in the patients with poorly differentiated degree,
lymph node metastasis, or TNM III to IV, was significantly higher than that of the patients with well-moderately differentiated, no lymphnode metastasis, or TNM I to II respectively (P < 0.05). However the VIP expression intensity had not significant different in the sex, age, or cancer location (P > 0.05) 3. The positive expression rates of CD80 in the inflammatory cells of gastric carcinoma tissue (33%) was significantly lower than that in normal peripheral tissue (60%) (P < 0.01). The expression intensity of CD80 in the inflammatory cells of gastric carcinoma was significantly
lower than that in normal peripheral tissue (P < 0.01). Epacadostat price The CD80 expression intensity in the inflammatory cells of gastric carcinoma in the patients with lymph node metastasis, or TNM III to IV, was significantly lower than that of the patients with no lymphnode metastasis, or TNM I to II respectively (P < 0.05). However the CD80 expression intensity had not significant different in the sex, age, cancer location, or differentiation degree (P > 0.05) 4. The positive expression rates of CD86 in the inflammatory cells of gastric medchemexpress carcinoma tissue (35%) was significantly lower than that in normal peripheral tissue (60%) (P < 0.05). The expression intensity of CD86 in the inflammatory cells of gastric carcinoma was significantly lower than that in normal peripheral tissue (P < 0.01). The CD86 expression intensity in the inflammatory cells of gastric carcinoma in the patients with TNM III to IV was significantly lower than that of the patients with TNM I to II (P < 0.01). The CD86 expression intensity in the inflammatory cells of gastric carcinoma in the patients with poorly differentiated degree or lymph node metastasis was lower than that of the patients with well-moderately differentiated degree or no lymphnode metastasis respectively (P > 0.05).