Results: There were 223 cases with SAS or SDS score ≥50 in 318 FGIDs KU-60019 concentration (70.4%).

The difference of Anxiety Scale and Depression Scale between disease groups and the normal controls group had statistical significance (P < 0.05), but among disease groups, it had no statistical significance (P > 0.05). Conclusion: Patients with FGIDs are accompanied with depression and anxiety psychological obstacle, and doctors should fucuse on it. Key Word(s): 1. FGIDs; 2. anxiety; 3. depression; 4. psychological test; Presenting Author: SAYED ABBAS- HAGHAYEGH Additional Authors: PEIMAN- ADIBI Corresponding Author: PEIMAN- ADIBI Objective: Sleep Disorders are one of most common of comorbid problem in irritable bowel syndrome (IBS) patients The purpose of this research, was the determine the efficacy of Dialectical Behavioral Group Therapy on sleep

problems (early, maintain and wake-up) of IBS patients. Methods: Therefore, 52 IBS patients who received this diagnosis, according the Rome GDC-0980 datasheet II criteria, were selected and assigned to two experimental and control groups with 26 IBS patients in each group-according to Mooshine s manual-. The experimental group received 8 weekly sessions in the clinic of gastroentology in in Isfahan. The questionnaire of sleep problems was used as the pretest, post-test, follow-up). Results: Results of multi analysis of variance (MANOVA)

showed that there is significant difference the mean post-test scores of beginning of sleep problems between two groups. There was also significant difference in beginning of sleep problems and wake-up in follow-up. (p < 0.005). There was no significant difference in mean score of maintain sleep. Conclusion: Findings support rather the efficacy of MCE Dialectical Behavioral Group Therapy in improvement of sleep problems IBS patients. Key Word(s): 1. IBS; 2. DBT; 3. sleep problems; Presenting Author: JUNYING XU Additional Authors: WEI DING Corresponding Author: JUNYING XU Affiliations: no Objective: To investigate the therapeutic effects of deanxit combined with proton pump inhibitors in treating non-erosive gastroesophageal reflux disease (NERD) with anxiety and depression. Methods: Totally 54 NERD patients were diagnosed with NERD accompanied with mild anxiety and/or depression according to HAD score, HAMA score, and HAMD score. They were randomly divided into two groups: 18 patients in Group A (proton pump inhibitor group) and 36 patients in Group B (deanxit combined with proton pump inhibitor group). Patients in Group A were treated with Esomeprazole 20 mg twice daily for 8 weeks, while those in Group B were treated with Esomeprazole 20 mg and deanxit 10 mg twice daily for 8 weeks.