Results: There were minor
to moderate differences in the absolute tissue SNR and CNR values and in qualitative appearance of brain images obtained by using ultra-low-SAR and high-SAR techniques. High-SAR 2D T2-weighted imaging produced slightly higher SNR, while ultra-low-SAR 3D technique not only produced higher SNR for T1-weighted and FLAIR images but also higher CNRs for all three sequences for most of the brain tissues.
Conclusion: The 3D techniques adopted here led to a decrease in the absorbed RF power by two orders of magnitude at 1.5 T, and still the image quality was preserved within clinically acceptable imaging times. (C)RSNA, 2011″
“The find more riboflavin (vitamin B(2)) biosynthetic genes in Bacillus subtilis are transcribed simultaneously from the riboflavin promoter (P(rib). The 5′-end of the nascent rib-mRNA carries a flavin mononucleotide (FMN) binding riboswitch, which regulates gene expression.
The antibiotic roseoflavin from Streptomyces davawensis is a naturally occurring riboflavin analog, its mechanism of action is largely unknown. A recombinant B. subtilis strain carrying a copy of P(rib)-RFN fused to a promoterless lacZ reporter gene in the chromosomal amyE AZD1480 concentration locus was grown in a minimal medium. Upon addition of roseoflavin to the growth medium the apparent LacZ activity in this strain was not significantly reduced. Similar experiments carried out on recombinant R subtilis strains oversynthesizing the flavin transporters RibU (B. subtilis) or RIM (S. davawensis) produced still other results. In these strains, roseoflavin (as well as riboflavin) repressed LacZ synthesis indicating that the RFN riboswitch is a target for roseoflavin (or roseoflavin SB202190 mononucleotide), which may at least in part explain its antibiotic activity.”
“Study Design. A fully blocked
experimental design using clinical vignettes to query primary care physicians on prescription for management of acute nonspecific low back pain.
Objective. To identify how nonclinical patient factors, specifically sex, patient presentation, and socioeconomic status, influence physician treatment recommendations for assessing and treating acute nonspecific low back pain.
Summary of Background Data. Adherence to evidence-based practice guidelines for nonspecific low back pain remains inconsistent. Therefore, it is important to understand what factors guide physician management of these cases.
Methods. One vignette and questionnaire was distributed to primary care and emergency department clinical physicians during meetings at five teaching hospitals.