The median (interquartile range, IQR) intake of PCB-153 (marker of ndl-PCBs) was 0.81 (0.77) ng/kg bw/day. For dioxins and dioxin-like PCBs, the median (IQR) intake
was 0.56 (0.37) pg TEQ/kg bw/day. Moreover, 2.3% of the participants had intakes exceeding the tolerable weekly intake (TWI) of 14 pg TEQ/kg bw/week. Multiple regression analysis showed that dietary exposure was positively associated with maternal age, maternal education, weight gain during pregnancy, being a student, and alcohol consumption during pregnancy and negatively associated with pre-pregnancy BMI and smoking. A high dietary exposure to PCB-153 or dl-compounds (TEQ) was mainly explained by the consumption of seagull eggs and/or pate with fish liver and see more Copanlisib roe. Women who according to Norwegian recommendations avoid these food items generally do not have dietary exposure above
the tolerable intake of dioxins and dl-PCBs. (C) 2013 Elsevier Ltd. All rights reserved.”
“Background: Hepatocyte growth factor (HGF) may stimulate angiogenesis. We examined the safety and therapeutic potential of the HGF plasmid (VM202) in pigs with chronic myocardial ischemia.
Methods and Results: We delivered VM202 or vehicle transendocardially to 4 groups of pigs: vehicle control (n = 9); high-dose VM202 (n 9); low-dose VM202 (n = 3); and normal control (no ischemia; n = 1). Pigs were killed 3, 30, and 60 days after injection. No adverse events were associated with VM202 treatment or delivery. Quantitative polymerase chain reaction indicated that heart injection sites had the highest levels of VM202 (day 3), which became almost undetectable by 30-60 days. Most nontarget sues showed clearance of VM202 plasmid by day 30. Control and VM202-treated pigs did not differ in global functional data. Dobutamine-stressed myocardial-contrast echocardiogram suggested that VM202 may help preserve microvascular perfusion at 30 days; reperfusion velocity in ischemic myocardium decreased significantly in
control (baseline to follow-up, 5.1 +/- 1.9 to 2.7 +/- 1.0; P = .031) but CA4P not in VM202 groups (high-dose: 3.1 +/- 1.1 vs 3.1 +/- 1.5 [P = .511]; low-dose: 3.8 +/- 1.1 vs 3.9 +/- 1.5 [P = .559]). Linear local shortening increased significantly from day 0 to 30 in VM202-treated versus control pigs (5.0 +/- 4.7% vs 9.2 +/- 7.5% vs 0.9 +/- 5.8% [high-dose, low-dose, control, respectively]; P = .021).
Conclusions: Transendocardial delivery of VM202 was safe and may help to preserve microcirculatory perfusion and improve wall motion. (J Cardiac Fail 2011:17:601-611)”
“The large demagnetizing currents in a single-phase line-start permanent magnet motor are generated by a starting and locked rotor condition.