Vitrification of fish spermatozoa without permeable cryoprotectants is a prospective direction for investigations: these cells can be successfully vitrified with 1% BSA + 40% seminal plasma.”
is a novel thiazolidinedione in clinical development for the treatment of type 2 diabetes. Common side effects associated with PPAR gamma receptor agonists are weight gain, oedema and adipogenesis. Balaglitazone is a selective partial PPAR gamma agonist and it has been speculated that such compounds have a more favourable safety margin than full agonists. We VX-680 have compared impact of equi-efficacious antihyperglycaemic doses of balaglitazone with full PPAR gamma agonist rosiglitazone on body fluid accumulation, cardiac enlargement, and adipogenesis. Equi-efficacious antihyperglycaemic doses (ED90) of balaglitazone (3 mg/kg/day) and rosiglitazone (6 mg/kg/day) were determined in male diabetic db/db mice. In adult male rats treated for up to 42 days, feeding, drinking, anthropometry, and plasma volumes were measured. Total plasma volume was measured with dye dilution technique. Compared to vehicle, rosiglitazone consistently increased food intake throughout the 42 day treatment period. In contrast, balaglitazone increased food intake in the last week of the experiment. However,
both rosiglitazone and balaglitazone increased water intake. INCB28060 clinical trial After 42 days, rosiglitazone treated rats displayed significantly elevated adiposity. Rosiglitazone Selleckchem XMU-MP-1 increased total blood and plasma volumes throughout the treatment. Twenty-one days of balaglitazone treatment had no significant impact on blood or plasma volumes, whilst 42 days of balaglitazone increased plasma volume but to a significantly lesser extent than seen for rosiglitazone (vehicle: 46.1 +/- 1.5; balaglitazone: 50.8 +/- 1.21: rosiglitazone: 54.6 +/- 1.6 ml/kg). Heart weight was significantly elevated only in rosiglitazone treated animals. At doses inducing comparable antihyperglycaemic control, the full PPAR gamma agonist, rosiglitazone, induces more pronounced body fluid retention and heart enlargement
than seen for the partial PPAR gamma agonist, balaglitazone. Thus, partial agonists may pose safer alternative to current antidiabetic therapy with full PPAR gamma agonist. (C) 2008 Elsevier B.V. All rights reserved.”
“Background: Adding adjuvants such as MF59 (R) to influenza vaccines can enhance the immune response. This analysis evaluated the safety profile of MF59-adjuvanted [(+)MF59] compared with non adjuvanted [(-)MF59] vaccines in a large clinical database.\n\nMethods: Safety data were pooled from 64 clinical trials involving (+)MF59 seasonal and pandem ic influenza vaccines. Safety outcomes were analysed in the overall population and in subjects aged >= 65 years, in all clinical trials and in controlled trials only.