5% or 5.0% of AP for the rest of 14 weeks after the administration of DSS. Sixteen weeks after AOM injection, all groups were sacrificed for histopathology analysis and the colon tumor assay. Key molecules of inflammation and proliferation pathway, such as MAPK Inhibitor Library IL-1β, IL-6, TNF-α, cyclooxygenase-2 (COX-2), myeloperoxidase (MPO)

and proliferating cell nuclear antigen (PCNA) were assessed by ELISA and Western blot from mice colonic mucosa. Results: Eight (100%), 6 (75%) and 4 (50%) mice in each AOM-treated group (G4-G6) developed cancers (P trend = 0.024). Among AOM-treated mice, significant reduction in tumor multiplicity and tumor size were observed in both groups fed with AP compared to the standard diet group (multiplicity: 10.1 ± 2.3 vs. 2.8 ± 0.9 and 2.6 ± 0.8 P = 0.025, P = 0.023; size: 5.8 ± 0.8 vs. 2.5 ± 0.8 and 2.4 ± 1.0, P = 0.025, P = 0.016). Also, significant reduction in COX-2 expression in the AOM-treated group with 5% AP and inhibition of IL-1β, IL-6, TNF-α, MPO and PCNA expressions in the AOM-treated groups with AP in a dose-dependent manner (all P < 0.05). Conclusion: Açaí reduced the incidence, multiplicity and size of AOM/DSS-induced Protease Inhibitor Library solubility dmso tumor in

mice. Açaí may have a potential to prevent colon carcinogenesis via anti-inflammatory and anti-proliferative properties. Key Word(s): 1. açaí; 2. colon cancer; 3. azoxymethane; 4. dextran Presenting Author: HYUN HO CHOI Additional Authors: CHUL HYUN LIM, MYUNG GUEN CHA, WON KYUNG KANG, JIN SU KIM, YU KYUNG CHO, JAE MYUNG PARK, BO INN LEE, IN SEOK LEE, SANG WOO KIM, MYUNG GYU CHOI Corresponding Author: HYUN HO CHOI Affiliations: The Catholic University of Korea, The Catholic University of Korea, The Catholic University of Korea, The Catholic University of Korea, The Catholic University of Korea, The Catholic University of Korea, The Catholic University of Korea, The Catholic University of

Korea, The Catholic University of Korea, The Catholic University of Korea Objective: In immunoglobulin G4(IgG4)-related disease is a relatively new disease entity characterized by elevated serum IgG4 levels and marked infiltration IMP dehydrogenase of IgG4-positive plasma cells in mass lesions. Organ enlargement or nodular lesions consisting of abundant infiltration of lymphocytes and IgG4-positive plasma cells and fibrosis are seen in various organs. IgG4-related disease has an older male predominance, with most patients in the 6th decade of life. We report a young female patient with an inflammatory pseudotumor of the low rectum, which was histopathologically confirmed to be IgG4-related disease. Methods: We retrospectively reviewed the medical records of a patient with IgG4-related disease of the low rectum. Results: The patient was a 28-year-young woman who presented with constipation for approximately 3 months.