927, P < 0.05). Compared with group B2, the expressions of SMA and FN protein in group C1 also decreased statistically at the end of 10 weeks (F = 77.421, 118.262, P < 0.05), and more significantly decreased in group H-FZHc C2 (P = 0.002, 0.013) proved by immunohistochemistry staining. At the same time the expressions of Nrf2 and Nqo1 protein were all increased statistically in groups L-FZHc C1 and

H-FZHc C2 at the end of 10 weeks demonstrated by immunohistochemistry staining (F = 182.537, 75.615, P < 0.05) and western-blotting (F = 45.664, 127.673, P < 0.05) comparing with group B2, and more notabally in group H-FZHc C2 (P = 0.000, 0.014; 0.005, 0.014). And also proved the amount of Nrf2 nuclear PD-0332991 order transportion and Nrf2 mRNA expression were increased higher in group C1 and C2 than group B2, and more significantly in group H-FZHc C2 (P = 0.044, 0.001). Conclusion: Fuzheng huayu compound can ameliorate the injury of hepatocytes in hepatic fibrosis in mice by exerting an anti-hepatic fibrosis effect via increase Nrf2

mRNA and protein expression and induce Nrf2 transport into nuclear, following by increasing the expression of target gene Nqo1, suppressing the activity of HSCs and decreasing the deposition of FN. Key Word(s): 1. Nrf2; 2. Fuzhenghuayu; 3. Liver fibrosis; 4. Nqo1; Presenting Author: PRAVEEN SHARMA Additional Authors: VARONICA ARORA, RINKESH BANSAL, ABDUL RAUF, PANKAJ TYAGI, NARESH BANSAL, VIKAS SINGLA, ASHISH KUMAR, ANIL ARORA Corresponding Author: PRAVEEN SHARMA Affiliations: SGRH Objective: Alcoholic selleck products hepatitis is associated with significant morbidity and mortality. Traditionally, Maddrey discriminant function (DF) score, Child-Turcott-Pugh (CTP) score and model for end-stage liver disease (MELD) score have been

used for stratifying the click here prognosis of alcoholic hepatitis. Liver stiffness measurement (LSM) value is influenced by changes in aminotransferases and serum bilirubin in patients with acute hepatitis and chronic liver disease. We aimed to evaluate and compare the predictive performances of LSM by Fibroscan with CTP, MELD and DF in predicting in hospital mortality. Methods: All consecutive patients with severe alcoholic hepatitis (DF > 32) were enrolled. Their CTP score, MELD score, DF score and LSM was done at baseline and at day 7. A change at day 7 was calculated (Δ change). Area under curve was calculated for predicting mortality of the patients. Results: Fifty two consecutive patients (age 43 ± 10 yr, M : F 52 : 0) were enrolled. Their baseline CTP score (9.4 ± 1.5), MELD score (23.2 ± 6.9), DF score (69 ± 28), LSM (64.1 ± 14.3 kPa), median bilirubin (12.5,5.3–32 mg%), median AST (120,40–340 U/l) and median ALT was (102,42–158 U/l). In hospital mortality was 15 (29%). There was significant difference (p < 0.01) at baseline between patients who got discharged versus those who died in CTP score (8.9 ± 1.1 vs 10.7 ± 1.8), MELD (22.1 ± 4.6 vs 27.0 ± 5.6), DF (59.8 ± 18.7 vs 91.0 ± 33.5) and LSM (61.3 ± 13.