7 (CH, Ar), 126 7 (CH, Ar), 127 4 (CH, Ar), 134 9 (CH, Ar), 149 3

N-Acetylisatin (1.39 g, 7.4 mmol) was dissolved in about 70 mL of ethanol and 2-aminobenzamide (1.00 g, 7.4 mmol) was added to the solution, covered with a watch glass and then irradiated in a microwave oven at 400 W for a total selleck chemicals of 10 min. 188–191 °C; δH (200 MHz, DMSO-d6) 2.0 (3H, BIBF 1120 ic50 s), 7.20–8.20 (8H, m, ArH), 11.20 (1H, s, NH), 12.50 (1H, s, NH); δC (50 MHz, DMSO-d6) 25.1 (CH3), 121.7 (Cq, Ar), 122.4 (CH, Ar), 123.8 (CH, Ar), 126.5 (CH, Ar), 127.5 (CH, Ar), 127.6 (CH, Ar), 130.3 (CH, Ar), 132.0 (CH, Ar), 135.3 (CH, Ar), 138.4 (Cq, Ar), 148.5 (C N), 153.7 (C O), 162.9 (C O), 168.9 (C O). Oxalic acid dihydrate (0.93 g, 7.4 mmol) was dissolved in 30 mL of ethanol and 2-aminobenzamide (1.00 g, 7.4 mmol)

was added to the resulting solution, stirred to dissolution, covered with a watch glass and then irradiated in a microwave oven at 400 W for a total of 10 min to give a solution, which upon cooling and recrystallization afforded 3,4-dihydro-4-oxoquinazoline-2-carboxylic acid as a white solid (2.04 g, 89%), m.p. 196–198 °C; δH (200 MHz, DMSO-d6) 6.50–8.40 (8H, m, ArH), 8.60 (2H,s, NH), 12.90 (1H, s, OH); δC (50 MHz, DMSO-d6) 115.1 (CH, Ar), 117.1 (CH, Ar), 120.6 (CH, Ar), 121.2 (Cq, Ar), 124.4 (CH,

Ar), 129.4 (CH, Ar), 132.6 (CH, Ar), 133.1 (CH, Ar), 138.8 (Cq, Ar), 150.8 (Cq, Ar), 156.6 (Cq, Ar), 161.7 (C N), 162.2 (C O), 170.9 (C O), 172.0 (C O). 2-Aminobenzamide (1.0 g, 7.4 mmol) was dissolved in 15 ml of acetic acid in a round-bottomed flask. 0.7 mL of bromine was added to the flask and the mixture refluxed for 30 min. On cooling, 40 mL of water was added to the mixture in the flask and refluxed for another 30 min. The product was then filtered hot and finally recrystallized from ethanol to furnish 2-amino-3,5-dibromo-benzamide Carnitine palmitoyltransferase II as a white solid (1.78 g, 82%), m.p. 210–212 °C; υmax/cm−1 (KBr) 3370, 3184 (NH), 1637 (C O of amide), 1607 (C C); δH (200 MHz, CDCl3) 6.80 (2H, s, NH, D2O Modulators exchangeable), 7.50 (1H, s, NH, D2O exchangeable), 7.70 (1H, s, ArH), 7.80 (1H, s, ArH), 8.10 (1H, s, NH, D2O exchangeable); δC (50 MHz, CDCl3) 105.7 (Cq, Ar), 111.1 (Cq, Ar), 117.5 (Cq, Ar), 131.4 (CH, Ar), 137.3 (CH, Ar), 146.6 (Cq, Ar), 170.0 (C O); m/z (rel. %): 296 [M+ (81Br2), 78), 277 (100), 251 (40). The antibacterial activities of compounds 3, 5–9 were determined in accordance with agar-well diffusion method described by Russell and Furr14 and Akinpelu and Kolawole.

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