AST and ALT were significantly higher in the control group. The serum levels of cholesterol and LDL-cholesterol showed a tendency toward lower values in the
control group. We found positive correlation between serum levels of insulin and HOMA IR with staging (respectively r=0.336, P < 0.04 and r=0.386, P < 0.02).
Conclusions: In children with CHC and a relatively short duration of the disease, lipid and glucose disorders are not observed. Correlations between insulin and HOMA IR with staging suggest the ability of HCV to contribute to fibrosis through interference with glucose metabolism.”
“Background: Osteochondrosis (OC) is a common developmental orthopedic disease affecting both humans and animals. Despite increasing recognition ML323 Ubiquitin inhibitor of this disease among children and adolescents, VX-680 chemical structure its pathogenesis is incompletely understood because clinical signs are often not apparent until lesions have progressed to end-stage, and examination of cadaveric early lesions is not feasible. In contrast, both naturally-occurring and surgically-induced animal models of disease have been extensively studied, most notably in horses and swine, species in which
OC is recognized to have profound health and economic implications. The potential for a translational model of human OC has not been recognized in the existing human literature.
Objective: The purpose of this review is to highlight the similarities in signalment, INCB28060 in vitro predilection sites and clinical presentation of naturally-occurring OC in humans and animals and to propose a common pathogenesis
for this condition across species.
Study design: Review.
Methods: The published human and veterinary literature for the various manifestations of OC was reviewed. Peer-reviewed original scientific articles and species-specific review articles accessible in PubMed (US National Library of Medicine) were eligible for inclusion.
Results: A broad range of similarities exists between DC affecting humans and animals, including predilection sites, clinical presentation, radiographic/MRI changes, and histological appearance of the endstage lesion, suggesting a shared pathogenesis across species.
Conclusion: This proposed shared pathogenesis for OC between species implies that naturally-occurring and surgically-induced models of DC in animals may be useful in determining risk factors and for testing new diagnostic and therapeutic interventions that can be used in humans. (C) 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.”
“To review published studies regarding the use, feasibility and psychometric performance of the schedule for the evaluation of individual quality of life-direct weighting (SEIQoL-DW) in clinical research.
Systematic literature review. Studies using the SEIQoL-DW were included if they were published in English and employed a quantitative design.