Eur J Clin Pharmacol 64:1139–1146PubMedCrossRef Foresman JB, Frisch A (1998) Exploring chemistry with electronic structure methods. Gaussian, Inc., Pittsburg Frisch MJ, Trucks GW, Schlegel HB, Scuseria GE, Robb MA, Cheeseman JR et al (2004) Gaussian 03, Revision D.01. Gaussian, Inc., Wallingford Fumagalli L, Bolchi C, Colleoni S, Gobbi M, Moroni B, Pallavicini M et al (2005) QSAR study for a novel series of ortho monosubstituted phenoxy analogues of α1-adrenoceptor

antagonist WB4101. Bioorg Med Chem 13:2547–2559PubMedCrossRef Gálvez J, Garcìa R, Salabert MT, Soler R (1994) Charge indexes. Apoptosis inhibitor New topological descriptors. J Chem Inf Comput Sci 34:520–525CrossRef Gálvez J, Garcìa-Domenech R, De Julián-Ortiz V, Soler R (1995) Topological approach to drug BI 10773 cost design. J Chem Inf Comput Sci 35:272–284PubMedCrossRef Gálvez J, Garcìa-Domenech R, de Gregorio Alapont C, De Julián-Ortiz V, Popa L (1996) Pharmacological distribution diagrams: a tool for de novo drug design. J Mol Graphics 14:272–276CrossRef Golan DE (2008) Principles of pharmacology: the pathophysiologic Inhibitor Library datasheet basis of drug therapy. Lippincott Williams & Wilkins, London Golbraikh A, Tropsha A (2002) Beware of q2!. J Mol Graphics Mod 20:269–276CrossRef Goldberger JJ, Cain ME, Hohnloser SH, Kadish AH, Knight BP, Lauer MS et al (2008) American Heart Association/American

College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for identifying patients at risk for sudden cardiac death. A scientific statement from the American Heart Association Council on Clinical Cardiology Committee on Electrocardiography and Arrhythmias and Council on Epidemiology and Prevention. J Am Coll Cardiol 52:1179–1199PubMedCrossRef Graham RM, Perez DM, Hwa J, Piascik MT (1996) α1-Adrenergic receptor subtypes molecular structure, function, and signaling. Cir Res 78:737–749 Gramatica P (2007) Principles of QSAR models validation: internal and external. QSAR Comb Sci 26:694CrossRef Hashimoto K (2007) Arrhythmia models for

drug research: classification of antiarrhythmic drugs. J Pharmacol Sci 103:333–346PubMedCrossRef Hawkins DM, Basak SC, Mills D (2003) Calpain Assessing model fit by cross-validation. J Chem Inf Comput Sci 43:579–586PubMedCrossRef He Z, Huang L, Wu Y, Wang J, Wang H, Guo L (2008) DDPH: improving cognitive deficits beyond its α1-adrenoceptor antagonism in chronic cerebral hypoperfused rats. Eur J Pharmacol 588:178–188PubMedCrossRef Huikuri HV, Castellanos A, Myerburg RJ (2001) Sudden death due to cardiac arrhythmias. N Engl J Med 345:1473–1482PubMedCrossRef Jain KS, Bariwal JB, Kathiravan MK, Phoujdar MS, Sahne RS, Chauhan BS et al (2008) Recent advances in selective α1-adrenoreceptor antagonists as antihypertensive agents.