Once an ovarian origin was confirmed, total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed for definitive treatment. The adrenal adenoma was left in situ. There was a dramatic decrease Cell Cycle inhibitor in subjective symptomatology and normalization of testosterone postoperatively.

CONCLUSION: Preoperative differential venous sampling determined the correct source of testosterone. Subsequent removal of the ovary and steroid cell tumor correctly treated the hyperandrogenism and avoided an unnecessary surgical procedure for the adrenal adenoma. (Obstet Gynecol 2012;120:476-9) DOI: 10.1097/AOG.0b013e31825a711c”
“The ankle-brachial index (ABI) is used

in the screening diagnosis of peripheral artery disease (PAD). Lower limb ischemia is diagnosed selleck chemicals if ABIa parts per thousand currency sign0.9. However, persons with ABI > 1.4 also suffer from leg ischemia. Not taking this into consideration may lead to diagnostic mistakes and an underestimation of cardiovascular risk.

This study addresses the analysis of clinical conditions related to an elevated ABI.

One hundred and twenty-two randomly chosen subjects over 50 were treated in internal medicine ward were studied using questionnaire and ABI determination.

Forty-four (34%) patients had elevated ABI > 1.4 and in 23 (19%) subjects ABI wasa parts per thousand currency sign0.9. Patients with ABI > 1.4,

in comparison to individuals with 0.9 < ABIa parts per thousand currency sign 1.4, presented significantly greater BMI, more atherosclerosis risk factors, more prevalent past stroke and angina pectoris. In comparison to patients with ABIa parts per thousand currency sign0.9, they showed higher blood pressure and lower LDL cholesterol concentration. In the

diagnosis of ABI > 1.4, lack of palpable pulse in at least one lower limb artery had CUDC-907 cell line a sensitivity of 6.8%, specificity of 91%, PPV of 30%, NPV of 63.4%, a likelihood ratio positive 0.75 and for negative 1.02; pulse pressure above 55mmHg had similar low diagnostic yield, respectively: 36.4%, 71.8%, 42.1%, 66.7%, 1.29 and 0.89. In logistic regression only LDL value was a significant predictive factor for elevated ABI, but with a very low odds ratio value for separate increments.

In the diagnosis of lower limb ischemia and connected cardiovascular risk, ABI determination should be obligatory, besides atherosclerosis risk factors, peripheral pulse and pulse amplitude determination.”
“Objective.

Injury is a common initiating event for persistent pain. The presentation of injured patients to hospital represents an opportunity to identify patients at high risk of persistent pain and triage them to early intervention. Although a range of physical, psychological, and social risk factors have been implicated in the transition from acute to persistent pain, these factors have not been tested concurrently in a prospective study.

These doctors were asked what choice they believe they would make for their own affected infant. Comparison of responses from 1999 and 2007 showed no difference in the responses of cardiologists: 1999 (44 % surgery, 17 % palliative treatment, 40 % uncertain) versus 2007 (45 % surgery, 20 % palliative

treatment, 35 % uncertain). Among surgeons, there was a non-statistically significant trend away from choosing surgery: 1999 (77 % surgery, 5 % palliative PD-L1 inhibitor treatment, 18 % uncertain) versus 2007 (56 % surgery, 8 % palliative treatment, 36 % uncertain). In conclusion, these analyses suggest that despite improving surgical outcomes, doctors are no more likely to predict that they would choose surgery for their own hypothetical infant with HLHS. Further research is needed

to determine what factors influence choice making in the care of infants with HLHS.”
“SETTING: Although considerable effort has been put into the development and evaluation NVP-HSP990 order of new diagnostics for tuberculosis (TB) and multidrug-resistant TB (MDR-TB), little attention has thus far been paid to the technical aspects of initiating quality-assured routine service use. For implementation of the microscopic-observation drug susceptibility (MODS) methodology in the Peruvian reference laboratory network, a laboratory accreditation process was devised; MODS results from an expert reference laboratory (Universidad Peruana Cayetano Heredia [UPCH]) were used as the standard against which implementing laboratory MODS results were judged to ensure that, prior to use for patient care, implementing laboratories achieved the same high performance with MODS as previously demonstrated in the research laboratory.

OBJECTIVE:

To evaluate the validity of MODS-based accreditation and the concordance of MODS drug susceptibility testing (DST) with molecular testing.

DESIGN: Head-to-head comparison of MODS DST results from implementing Peruvian regional reference laboratories and the accrediting expert MODS laboratory (UPCH) with GenoType (R) MTBDRplus DST.

RESULTS: The concordance of phenotypic MODS rifampicin (RMP) DST with GenoType MTBDRplus was respectively 97.4%, 97.9% and 97.1% for the two implementing regional laboratories and UPCH, and MDV3100 respectively 94.7%, 95.7% and 94.6% for isoniazid (INH) DST. CONCLUSION: High and consistent levels of MODS/MTBDRplus concordance for INH and RMP DST confirm the validity of the use of rapid methods as reference standards for accreditation.”
“The objective of this study was to compare histopathological changes in hypoplastic left heart syndrome right ventricles (RV) of patients undergoing Sano and modified Blalock-Taussig (MBT) shunt and correlate them with echocardiographic findings. Myocardial tissue samples were obtained from hearts with Sano or MBT shunts after transplantation or at autopsy. Histologic sections were reviewed manually and by automated digital image analysis.

4%). Primary glomerulonephritis (GN) was the most common finding (57.4%), followed by secondary GN (15.5%) and tubulointerstitial diseases (4.5%). According to histopathological diagnosis, the most common causes of primary GN were

focal segmental SB203580 mw glomerulosclerosis (20.9%), mesangioproliferative GN (14.6%), IgA nephropathy (8.9%) and minimal change disease (13%). Lupus nephritis (6%) and Henoch-Schonlein nephritis (4%) were the most common secondary glomerular diseases.

Conclusions: The epidemiology of glomerular disease in our single-center report is similar to that in data from adjacent Croatia and Greece. Focal segmental glomerulosclerosis was the dominant histopathological finding, followed by mesangioproliferative GN and IgA nephropathy.”
“Background: The aim of our study was to analyze the efficacy and safety of rituximab, a chimeric monoclonal antibody against CD20 lymphocytes, as a nonstandard immunosuppressive therapy in

children with different types of primary AZ 628 mw glomerulonephritis who were not eligible for routine treatment.

Methods: The study group was composed of 16 children with proteinuric glomerulopathies, not responding to standard immunosuppressive therapy. The indications included steroid-resistant nephrotic syndrome (n=14) and steroid-dependent nephrotic syndrome (n=2). The dose of rituximab was established as 375 mg/m(2) of body surface area, administered by intravenous infusion once weekly for 1 to 4 weeks, depending on the CD19 lymphocyte count. We evaluated proteinuria and plasma concentration of CD19 lymphocytes at intervals of 1, 3 and 6 months, after which patients received a single repeat dose.

Results: Remission, defined as proteinuria less than 150 mg per 24 hours, was observed in 7 of the 16 children. There were no statistically significant differences in leukocyte counts between single and multiple rituximab doses. We also did not observe any clinical or biochemical side effects.

Conclusions:

In conclusion, we postulate that alternative PF-6463922 inhibitor rituximab therapy should be taken into consideration in nephrotic patients not responding to standard therapy.”
“Objectives: To promote a broader understanding of the psychosocial impact of childhood cancer on siblings, a systematic review was undertaken. Directions for future research are proposed and clinical strategies are suggested for addressing the needs of these children.

Methods: Searches of Medline, PsycINFO and CINAHL revealed 65 relevant qualitative, quantitative, or mixed methods’ papers published between 1997 and 2008. These papers were rated for scientific merit and findings were extracted for summary.

Results: Siblings of children with cancer do not experience elevated mean rates of psychiatric disorders, but a significant subset experiences post-traumatic stress symptoms, negative emotional reactions (e.g. shock, fear, worry, sadness, helplessness, anger, and guilt), and poor quality of life in emotional, family, and social domains.

(c) 2011 American Institute of Physics. [doi:10.1063/1.3555620]“
“Because

it has a high demand for sulphur AZD5363 purchase (S), oilseed rape is particularly sensitive to S limitation. However, the physiological effects of S limitation remain unclear, especially during the rosette stage. For this reason a study was conducted to determine the effects of mineral S limitation on nitrogen (N) and S uptake and remobilization during vegetative growth of oilseed rape at both the whole-plant and leaf rank level for plants grown during 35 d with 300 mu M (34)SO(4)(2-) (control plants; +S) or with 15 mu M (34)SO(4)(2-) (S-limited plants; -S). The results highlight that S-limited plants showed no significant differences either in whole-plant and leaf biomas or in N uptake, when compared with control plants. However, total S and (34)S (i.e. deriving from S uptake) contents were greatly reduced for the whole plant and leaf after 35 d, and a greater redistribution of endogenous S from leaves to the benefit of roots was observed. The relative expression of tonoplast and plasmalemma sulphate transporters ATM Kinase Inhibitor inhibitor was also strongly induced in the roots. In conclusion, although S-limited plants had 20 times less mineral S than control

plants, their development remained surprisingly unchanged. During S limitation, oilseed rape is able to recycle endogenous S compounds (mostly sulphate) from leaves to roots. However, this physiological adaptation may be effective only

over a short time check details scale (i.e. vegetative growth).”
“Organ donor shortage for infant liver transplant recipients has lead to an increase in splitting and living donation. For cases in which even transplantation of the left lateral graft (Couinaud’s segments II + III) results in a “”large for size situation”" with an estimated graft body weight ratio (GBWR) of >4%, monosegmental liver transplantation was developed. This, however, bears complications because of greater parenchymal surface and suboptimal vascular flow. We exclusively use the left lateral graft from living donors or split grafts. Temporary abdominal closure is attempted in cases of increased pressure. We report of 41 pediatric transplants in 38 children <= 10 kg. Within this group, there were 23 cases with a GBWR of 4, and 15 cases with a GBWR <4. There was no statistical difference in vascular or biliary complications. Despite a more frequent rate of temporary abdominal closure, we did not find a higher rate of intra-abdominal infections. Overall, patient and graft survival was excellent in both groups (one death, three re-transplants). We noticed, however, that the ventro-dorsal diameter of the graft appears to be more relevant to potential graft necrosis than the actual graft size.

(C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 123: 1100-1111, 2012″
“Time evolution of the discharge plasma in the dielectric barrier discharge (DBD) plasma actuator was simulated by the simple fluid model in which the electron and single positive ion species were considered. Selleck OICR-9429 The characteristics

of the discharge plasma evolution were investigated in detail, and the following results were obtained. When the positive-going voltage is applied, the streamer discharge is formed periodically. The periodically formed streamer expands from the exposed electrode, and its length becomes longer than the previous one. Periodic breakdown of the gas and step-by-step plasma expansion are also observed during the negative-going voltage; however, the streamer is not formed and the breakdown frequency is much higher. The simulation results with a triangular applied voltage waveform show the same characteristics as observed in the experiment; large discharge current spikes are observed during both the positive- and negative-going voltage phase, and the plasma in

the negative-going voltage phase PFTα expands more smoothly than that in the positive phase because of its higher breakdown frequency. It was shown that even the simple numerical model could provide valuable insights into the physics of DBD plasma actuator; this indicates that the positive ions and electrons play a prominent role in determining the general characteristics of the plasma evolution. (C) 2011 American Institute of Physics. [doi:10.1063/1.3603001]“
“In murine models, the adoptive transfer of CD4+/CD25+ regulatory T cells (T(regs)) inhibited graft-versus-host disease (GvHD). Previous work has indicated a critical role for the adhesion molecule L-selectin (CD62L) in the function of T(regs) in preventing GvHD. Here we examined the capacity of naive wild-type (WT), CD62L-/- and ex vivo expanded CD62LLo T(regs) to inhibit Q VD Oph acute GvHD. Surprisingly, we found that CD62L-/- T(regs) were potent suppressors of GvHD, whereas CD62LLo T(regs) were unable to inhibit disease despite being functionally competent to suppress allo T cell responses in vitro.

Concomitant with improved outcomes, WT and CD62L-/- T(regs) significantly reduced liver pathology and systemic pro-inflammatory cytokine production, although CD62L-/- T(regs) were less effective in reducing lung pathology. While accumulation of CD62L-/- T(regs) in GvHD target organs was equivalent to WT T(regs), CD62L-/- T(regs) did not migrate as well as WT T(regs) to peripheral lymph nodes (PLNs) over the first 2 weeks posttransplantation. This work demonstrated that CD62L was dispensable for T(reg)-mediated protection from GvHD.”
“Mesh-like fiber mats of polystyrene (PS) were deposited using DC-biased AC-electrospinning. Superhydrophobic surfaces with water contact angles greater than 150 degrees and gas fraction values of up to 97% were obtained.

If the bicrystal is compressed further, dislocations within each grain are developed from the defects on the interface between grains. The configuration of the dislocations within grains is more regular when the applied twist angle is smaller. A Ni(111) bicrystal owns the largest amount of maximal stress no matter what the twist angle is. Those of a Ni(110) bicrystal is the second and of a Ni(100) bicrystal is the smallest. (C) 2011 American Institute of Physics. [doi:10.1063/1.3657948]“
“Class III peroxidases (Prxs) are plant enzymes capable of using H2O2 to oxidize a range of plant secondary KPT-330 metabolites, notably phenolic compounds. These enzymes

are localized in the cell wall or in the vacuole, which is a target for secondary metabolite accumulation, but very little is known about the function of vacuolar Prxs. Tariquidar ic50 Here, the physiological role of the main leaf vacuolar Prx of the medicinal plant Catharanthus roseus, CrPrx1, was further investigated namely by studying its capacity to oxidize co-localized phenolic substrates at the expense of H2O2. LC-PAD-MS analysis of the phenols from isolated leaf vacuoles detected the presence of three caffeoylquinic acids and four flavonoids in this organelle. These phenols or similar

compounds were shown to be good CrPrx1 substrates, and the CrPrx1-mediated oxidation of 5-O-caffeoylquinic acid was shown to form a co-operative regenerating cycle with ascorbic acid. Interestingly, more than 90% of total leaf Prx activity was localized in the vacuoles, associated to discrete spots of the tonoplast. Prx activity inside the vacuoles was estimated to be 1809 nkat ml(-1), which, together with the determined concentrations for the putative vacuolar phenolic substrates, indicate a very high H2O2 scavenging capacity, up to 9 mM s(-1). Accordingly, high light conditions, known to increase H2O2 production, induced both phenols and Prx levels. Therefore, it is proposed that the vacuolar couple Prx/secondary metabolites represent an important sink/buffer of H2O2 in green plant cells.”
“Background Evaluation of vascular

variants is crucial for donor assessment prior to living kidney transplantation. Both contrast-enhanced (CE) magnetic resonance angiography (MRA) and multislice Selleckchem 3-Methyladenine computed tomography (MSCT) are currently used for imaging living kidney donors. Aim of this study was the comparison of the accuracy of MSCT angiography and CE-MRA for the assessment of renal vascular anatomy. Methods Prospective study at a university transplant center including 65 potential living kidney donors. Pre-operative imaging by MSCT angiography and CE-MRA was correlated with the findings of laparoscopic donor nephrectomy in 48 donors. Results MSCT detected significantly more patients and more kidneys with accessory arteries than CE-MRA (p < 0.05). MSCT and CE-MRA performed similarly in identifying venous and ureteral abnormalities.

This diversity allows an ensemble of techniques to substantially broaden the biological scope and breadth of predictions. We also find that performing prediction and validation steps iteratively allows us to more completely characterize a biological area of interest. While this study focused on a specific functional area in yeast, Selleckchem SGC-CBP30 many of these observations may be useful

in the contexts of other processes and organisms.”
“A study was conducted to compare the efficacy and complications of TVT and TVT-O.

This study is a prospective randomized trial involving 300 women with primary SUI; 149 received TVT, and 151 patients were treated with TVT-O. At the 1 year follow-up, 141 TVT patients and 147 TVT-O patients (dropout, 5.3% and 2.6%) were evaluated using urodynamic studies, validated questionnaires, and a 1-h pad test.

The mean operating time was shorter in the TVT-O group (p < 0.001). Urinary retention was not significantly different (p > 0.05). Inner thigh discomfort was reported by 5.4% of TVT-O patients. In the TVT and the TVT-O groups, respectively, 90.1% and 88.4% women were objectively cured. The satisfaction with the surgical outcome reflects the significant decrease in the questionnaire

mean symptom scores in both groups. Postoperative de novo urgency was significantly more common in the TVT-O patients (p = 0.015).

The groups showed comparable objective and subjective cure rates.”
“Combinatorial library films of HfO2-TiO2-Y2O3, a high-k dielectric system, grown by pulsed find more laser deposition, exhibit visible boundary lines separating amorphous and crystalline phases. By changing processing space parameters, specifically substrate temperature during deposition,

as well as the composition Acalabrutinib clinical trial of the library film, we are able to manipulate the boundary and hence, the microstructural properties of the film. High-throughput x-ray diffraction and spectroscopic reflectometry are effective tools for measuring the properties of the resulting library films altered via these changes in processing. Electrical measurements confirm that the dielectric constant of the library films is composition and microstructure dependent. (C) 2010 American Institute of Physics. [doi:10.1063/1.3294607]“
“Midurethral sling (MUS) is now the first line surgical treatment for female stress urinary incontinence. Our aim was to identify predictors for MUS failure.

A total of 1,225 consecutive women with urodynamic urinary stress incontinence had a synthetic MUS (955 retropubic and 270 transobturator) at our institution between 1999 and 2007. Multivariate analysis was performed in order to identify independent risk factors for failure.

At a mean follow-up of 50 +/- 24 months (range, 12-114), the subjective cure rate was 84.7%. Multivariate analysis revealed that BMI > 25 (OR, 2.9), mixed incontinence (OR, 2.4), previous continence surgery (OR, 2.2), intrinsic sphincter deficiency (OR, 1.9), and diabetes mellitus (OR, 1.

Treatment of selected mutants confirmed that TSF and SOC1 are necessary for the flowering response to BAP, whereas the activation cascade might partially act independently of FD. These experiments provide a mechanistic basis for the role of cytokinins in flowering, and demonstrate that the redundant genes FT and TSF are differently regulated by distinct

floral-inducing signals.”
“The efficacy and safety of combined interferon (IFN) plus ribavirin in patients on long-term dialysis and chronic hepatitis C remains unclear, although a number of small clinical trials have addressed this issue. We evaluated the efficacy and safety HM781-36B nmr of combination antiviral therapy (conventional or pegylated interferon plus ribavirin) in dialysis patients with chronic hepatitis C by performing a systematic review of the literature with a meta-analysis of clinical trials. The primary outcome was sustained virological response (SVR) (as a measure of efficacy); the secondary outcome was drop-out rate (as a measure of tolerability). We used the random effects model of Der Simonian and Laird, with heterogeneity and sensitivity analyses. We identified 10 clinical studies (151 unique patients), one (10%) of which was a controlled clinical trial. Most (97.4%) patients were on long-term haemodialysis. The summary estimate

for SVR and drop-out rate was 56% [95% Confidence Intervals (95% CI) 28-84] and 25% (95% CI, 10-40), respectively. The most frequent side Ralimetinib in vivo SCH 900776 mw effects requiring interruption of treatment were anaemia (26%) and heart failure (9%). These results occurred irrespective of type of interferon (conventional or peg-IFN, peg-IFNalfa-2a or alfa-2b), trial design (controlled or cohort study), or clinical characteristics of patients (naive, nonresponders or relapsers). The studies were heterogeneous with regard to SVR and drop-out rate. Combination antiviral therapy (interferon plus ribavirin) gives encouraging results in terms of efficacy

and safety among dialysis patients even if the limited number of patients enrolled in our meta-analysis hampers definitive conclusions.”
“The use of small molecules has great power to dissect biological processes. This study presents the identification and characterisation of an inhibitor of peroxisome matrix protein import. A mini-screen was carried out to identify molecules that cause alteration in peroxisome morphology, or mislocalization of a peroxisome targeted fluorescent reporter protein. A benzimidazole lead compound (LDS-003655) was identified that resulted in reduced GFP fluorescence in peroxisomes and cytosolic GFP accumulation. The effect of the compound was specific to peroxisomes as Golgi bodies, endoplasmic reticulum and the actin cytoskeleton were unaffected even at 25 mu M, whereas peroxisome import via the PTS1 pathway was compromised at 100 nM.

X-ray absorption spectroscopy and diffraction show that epilayers and films contain MnP grains in the nanometric range with average Mn-P bond lengths very close to those of RO4929097 bulk MnP. The MnP film lattice parameters are almost identical to bulk values (within 0.5%) and the main crystallographic preferential orientations are those also present in the epilayers but with different relative populations. Overall the local structures of all MnP forms are very similar, except for indications of more disorder in the nanocrystals. Such combined changes of T(N) and T(C) are in apparent

contradiction with the known response of bulk MnP to strains induced by hydrostatic, uniaxial or chemical pressure. We conclude that the differences in the low temperature magnetic behavior are most probably originated by local structural disorder at the surface of the nanostructures and by finite size effects. (C) 2011 American Institute of Physics. [doi:10.1063/1.3580270]“
“When

two ferromagnetic layers have a common resonance frequency, the usual spin-pumping broadening may be reduced by dynamic exchange coupling. Utilizing BMS202 inhibitor the antiferromagnetic coupling between Co and Gd, we explore the change in ferromagnetic resonance accompanying a spontaneous transition from parallel to antiparallel magnetic alignment of two Co films below the compensation temperature T-comp. Above T-comp, the data are consistent with conventional models. However, a rapid doubling of magnetic damping accompanies the realignment,

which is reminiscent of resistivity changes in giant magnetoresistance. (C) 2011 American Institute of Physics. [doi:10.1063/1.3592298]“
“Meningococcal meningitis and septicemia are a persistent public health concern owing to the associated mortality and devastating long-term sequelae. People of all ages may be affected, with the disease burden being higher in at-risk groups. Vaccination is the most rational approach to the prevention of invasive meningococcal disease. A novel quadrivalent meningococcal (Men) serogroup A, C, W-135 and Y polysaccharide-protein conjugate vaccine (MenACWY-CRM), has recently been licensed for use in individuals aged at least Dihydrotestosterone datasheet 11 years old in the USA, Canada and Europe. One dose of MenACWY-CRM is well tolerated, and induces robust immunity to all constituent vaccine serogroups in 11-65 year old individuals. MenACWY-CRM was found to be noninferior to the quadrivalent meningococcal ACWY-diphtheria toxoid glycoconjugate vaccine, which is also licensed in the USA and Canada. In Europe, MenACWY-CRM is the first quadrivalent meningococcal glycoconjugate vaccine available to provide broader protection against Neissena meningitidis serogroups A, C, W-135 and Y.”
“Within the second-order perturbation approximation, the physical process of cumulative second-harmonic generation by the primary Lamb wave propagation has been investigated in the time domain.

In male individuals, BPH (OR 3.900; 95% Cl: 1.890-8.049) was another risk factor. Gender was not found to be associated with nocturia. Increasing episodes of nocturia (regression coefficient:

-2.564; 95% Cl: -3.08 to -2.049) and decreasing total sleeping hours (regression coefficient: 1.738; 95% Cl: 0.948-2.527) were independent factors predicting a significantly lower N-QOL score. Conclusions: Hypertension, diabetes and BPH are associated with nocturia, suggesting that multiple approaches are needed when treating patients with nocturia. Nocturia has a significant impact on the nocturia-related quality of life when the patient has 2 or more episodes PF-00299804 cell line per night. Copyright (c) 2011 S. Karger AG, Basel”
“The levels of serum enzymes and haemolytic effects of overdose of halofantrine hydrochloride were determined in adult male rats. The animals were grouped GPCR Compound Library into four groups and were orally administered halofantine hydrochloride in normal saline: 0 mg/kg (control), 4 mg/kg (under-dose), 8 mg/kg (normal dose) and 16 mg/kg (overdose) in three repeated doses at 6 h interval. The changes in serum enzyme levels were determined by monitoring the levels alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and total serum albumin. The haemolytic effect of the drug was monitored by the changes in Packed Cell Volume (PCV), total bilirubin and direct

bilirubin. There were significant increases in the ALT, AST and ALP levels in both the normal dose and overdose when compared with the control. The reduction in total serum albumin in normal dose and overdose was also significant (p < 0.05). The result also revealed a significant decrease in PCV and increase in total and direct bilrubin (p < 0.05) in the overdose groups. The result is indicative of the hepatotoxicity and haemotoxicity

of halofantrine hydrochloride VX-680 solubility dmso in normal dose and overdose conditions.”
“The capacity of hydrogen storage in alkali metal (Li, Na, or K), alkaline-earth metal (Be, Mg, or Ca), or Ti decorated borazine has been investigated by using the first-principles calculations based on density functional theory. Our results indicated that alkali metals could bind strongly to the inorganic molecule borazine and, especially, Li decorated borazine exhibits the highest hydrogen storage capacity up to 10.4 wt % theoretically. The adsorption energies of hydrogen molecules are in the range of -0.10 similar to-0.15 eV/H(2) (-0.23 similar to-0.28 eV/H(2) for local density approximation calculation) which are acceptable for reversible H(2) adsorption/desorption near ambient temperature. We also found that the hydrogen storage capacity of Ti decorated borazine is about 7.2 wt %, less than that of the Li decorated system, but the adsorption energies are in the range of -0.16 similar to-0.